Table 1 Antimicrobial activities of compounds 14

From: Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale

 

MIC (μg ml−1)

Organism (strain)

Staurosporine

1

2

3

4

Control

BCG (Mycobacterium bovis Pasteur 1173P2)

>100

>100

>100

>100

>100

0.05a

Methicillin-resistant S. aureusb

>100

>100

>100

>100

>100

1c

B. subtilis (ATCC 6633)

12.5

>100

>100

>100

>100

0.5c

P. aeruginosa (PAO1)

>100

>100

>100

>100

>100

1d

C. albicans (SC 5314)

0.1

>100

100

>100

>100

0.016e

C. albicans (SC 5314) synergisticf

0.1

6.25

0.78

>100

>100

1g

  1. Abbreviations: BCG, Bacillus Calmette–Guérin, MRSA, methicillin-resistant S. aureus.
  2. aIsoniazid.
  3. bMRSA, Clinical isolates, Beijing Chao-yang Hospital, Beijing, China.
  4. cVancomycin.
  5. dCiprofloxacin.
  6. eKetoconazole.
  7. fThe synergistic activity of tested compounds with triazole against C. albicans.
  8. gCyclosporin A.