Table 2 Growth inhibition activity of 1 against various recombinant S. cerevisiae

From: Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

  

Drug-sensitive S. cerevisiae

ΔAAC S. cerevisiae

Compound

μg per disc

Glycerol medium

Glucose medium

Empty vector strain

Tribolium castaneum strain

Acyrthosiphon pisum strain

1

10.0

13.5

 

3.0

8.5

 

1.0

 

0.3

Strobilurin B

3.0

45.4

47.0

16.5

 

1.0

40.0

46.6

15.3

 

0.3

39.2

45.6

 

0.1

37.7

41.6

Carboxin

3.0

20.9

19.1

24.1

 

1.0

13.4

13.5

17.0

 

0.3

7.3

8.7

10.0

 

0.1

  1. Results of paper disc assays of various S. cerevisiae strains. The drug-sensitive BY25929 strain was cultured in glycerol- or glucose-containing medium. Three endogenous AAC-disrupted and single-copy-type yeast shuttle vector pRS314YA2P-expressing strain were used. An ‘Empty vector’ strain was cultured in glucose-containing medium, and Tribolium castaneum AAC-expressing and Acyrthosiphon pisum AAC-expressing organisms were cultured in glycerol-containing medium. Test compounds were dissolved in MeOH at appropriate concentrations. Inhibition zone diameters are shown in millimeters. –; No inhibition.