Abstract
In the course of our screening for activators of hypoxia-inducible factor (HIF), A-503451 A and virantmycin were isolated from the cultured broth of an actinomycete strain, Streptomyces sp. SANK 60101. From the same culture, the non-active homologs A-503451 B and D were also isolated. A-503451 A and virantmycin activated HIF-dependent reporter gene expression with EC50 values of 8 and 17 ng ml−1, respectively. They are highly potent activators of HIF and thus may be therapeutically useful for erythropoiesis and neural cell protection.
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We are deeply grateful to Ms Yasuko Kono for assistance, and Dr Toshio Takatsu and Dr Masatoshi Inukai for their useful advice.
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Hirota-Takahata, Y., Kobayashi, H., Kizuka, M. et al. Studies on novel HIF activators, A-503451s.. J Antibiot 69, 747–753 (2016). https://doi.org/10.1038/ja.2016.17
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DOI: https://doi.org/10.1038/ja.2016.17
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