Table 4 Spontaneous mutation frequency of Ramizol for C. difficile isolates in agar

From: Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis

Strain

MIC

MIC multiple for mutant selection

Mean inoculum size (CFU ml−1)

Colony counts

Mutation frequency

C. difficile ATCC 700057

16

8 ×

1.3 × 1013

0

<7.69 × 10−13

  

4 ×

 

0

 

C. difficile ATCC 43255

16

8 ×

1.0 × 1013

0

<1.0 × 10−12

  

4 ×

 

0

 
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