Abstract
Two novel γ-butyrolactones ghanamycins A (1) and B (2) were isolated from the fermentation broth of marine-derived Streptomyces ghanaensis TXC6-16. Their structures were elucidated by spectroscopic analysis. These two novel compounds exhibited antimicrobial activities against some phytopathogens. The minimum IC (MIC) of 2 against Pseudomonas syringae and Erwinia sp. were 50 μg ml−1.
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Acknowledgements
This work was financially supported by the High-Tech Program (863 Program) of China (2008AA09Z407), National Natural Science Foundation of China No. 40776098 and 40976104, and the National Special Fund for State Key Laboratory of Bioreactor Engineering, Grant No 2060204.
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Xu, Jh., Gu, Kb., Zhang, DJ. et al. Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16. J Antibiot 70, 733–736 (2017). https://doi.org/10.1038/ja.2017.37
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DOI: https://doi.org/10.1038/ja.2017.37
