Summary
We determined plasma apolipoprotein H (β2-glycoprotein I) levels in 300 healthy adult individuals and evaluated the frequencies of theBg N andBg D alleles in a Japanese population. These results were then compared with the previous reports. The plasma apo H levels in the subjects showed bimodal distribution: 274 subjects were in the range 15.6–33.2 mg/dl and were considered to be homozygous forBg N (phenotype NN), and 26 subjects were found in the range 9.6–14.8 mg/dl and were presumably heterozygous forBg N andBg D (phenotype ND). In this study, no sample below 5 mg/dl (phenotype DD) was found. Mean plasma apo H levels in NN and ND groups were 22.1±1.6 mg/dl and 12.5±1.6 mg/dl, respectively. The gene frequencies ofBg N andBg D in a Japanese population were 0.957 and 0.043, respectively. These results were similar to gene frequencies ofBg N andBg D in Caucasoids.
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Takamatsu, K., Kishino, W., Suehiro, T. et al. Plasma apolipoprotein H (β2-glycoprotein I) phenotype frequencies in a Japanese population. Jap J Human Genet 34, 279–283 (1989). https://doi.org/10.1007/BF01929209
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DOI: https://doi.org/10.1007/BF01929209
