Abstract
Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13–p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15–q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13–p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935–D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13–p12.
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Acknowledgements
We thank all patients for participating in this study, T. Amano in Kyushu University and T. Baba in SRL, Inc., for collecting the samples, and A. Murakami, E. Yachi, K. Ohki, and T. Fujimoto for technical assistance. This work was supported by the Program for Promotion of Fundamental Studies in Health Sciences of Pharmaceuticals and Medical Devices Agency (PMDA).
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Collaborating groups listed in alphabetic order: Nobuyuki Abe (Abe Diabetes Clinic), Katsumi Eguchi (Nagasaki University), Nobuaki Fujio (Beppu Medical Center), Masafumi Haji (Kyushu Rosai Hospital), Mine Harada (Kyushu University), Sinsuke Hiramatsu (Kyushu Medical Center), Mitsuo Iida (Kyushu University), Minako Imamura (Kyushu University), Hidehiro Ishii (Kitakyushu Municipal Medical Center), Eiji Kawasaki (Nagasaki University), Kunihisa Kobayashi (Kyushu University), Ichiro Komiya (University of the Ryukyus), Shiori Kondo (Matsuyama Red Cross Hospital), Yasuko Kono (Imamura Hospital), Nobuyuki Koriyama (Kagoshima University), Minoru Kuriyama (Social Health Insurance Inatsuki Hospital), Kazunari Matsumoto (Sasebo Central Hospital), Kazuo Mimura (Fukuoka Medical Association Hospital), Isao Morimoto (Inoue Hospital), Mieko Nakayama (Kyushu University), Shyoichi Natori (Aso Iizuka Hospital), Yosuke Okada (University of Occupational & Environmental Health), Haruka Sasaki (Fukuoka University), Naotaka Sekiguchi (Kyushu University), Yasunori Sera (Sasebo Central Hospital), Michio Shimabukuro (University of the Ryukyus), Yuji Tajiri (Fukuoka Medical Association Hospital), Chuwa Tei (Kagoshima University), Maiko Tsuda (Kitakyushu Municipal Medical Center), Takero Uemura (Yatsushiro General Hospital), Eiji Kawasaki (Nagasaki University).
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Nawata, H., Shirasawa, S., Nakashima, N. et al. Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese. J Hum Genet 49, 629–634 (2004). https://doi.org/10.1007/s10038-004-0199-3
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DOI: https://doi.org/10.1007/s10038-004-0199-3
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