Abstract
Prostate cancer (PC) is one of the most common causes of cancer mortality in Western countries, and familial aggregation of PC is well known. Multiple PC susceptibility loci have been reported in Western countries, but attempts to confirm the loci in independent data sets have proven to be inconsistent. We performed a genomewide linkage analysis with 53 affected sib pairs to identify genetic loci related to PC in a Japanese population. Two linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to PC at chromosome 1p and 8p, which were reported as being loci for PC in Caucasians. The best evidence of linkage was detected near D8S550 on 8p23 (maximum Zlr=2.25, P=0.037), and the second-best evidence of linkage was observed near D1S2667 on 1p36 (maximum Zlr=2.24, P=0.034). This is the first genetic mapping of PC in Japanese, and the results suggest that susceptibilities to PC lie close to D8S550 on 8p23 and D1S2667 on 1p36.
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Acknowledgments
We thank DNA donors for making this study possible, and we thank the following doctors for registration of familial prostate cancer in this study: Takanori Suzuki, Hirotomo Takahashi, Yotsuo Higashi, Takeo Makino, Isao Kurosawa, Hisanori Yajima, Jun Kurihara, Kazuhisa Saruki, Kazuhiko Okabe, Koichi Kitaura, Yoshimi Tamura, Tetsuo Sekihara, Nobuo Kato, Kazunori Ebihara, Hideo Kiren, Yoshio Ichinose, Susumu Jinbo, Tadatoshi Shinozaki, Masaya Miki, Mikio Kobayashi, Hiroyuki Jinbo, Nozomu Kosaku, Kiyotaka Tsuchiya, and all other collaborators for collecting samples. We acknowledge Katsunori Ikari and Tetsutaro Yamaguchi for their supports of data analyses and Ms. Yasuda and Ms. Nakamura for their technical efforts. This work was supported in part by a Research for the Future Program Grant of The Japan Society for the Promotion of Science (II), and Grant-in-Aid for scientific research from the Japanese Ministry of Education, Science, Sports and Culture (II, HY).
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Matsui, H., Suzuki, K., Ohtake, N. et al. Genomewide linkage analysis of familial prostate cancer in the Japanese population. J Hum Genet 49, 9–15 (2004). https://doi.org/10.1007/s10038-003-0099-y
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DOI: https://doi.org/10.1007/s10038-003-0099-y
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