Table 7 Regression analysis for age-, gender-, atopy-, and smoking-adjusted log (Total IgE) with polymorphisms in the IL1A, IL1B, IL2, IL3, IL4, IL5RA, IL8, and IL10 genes among bronchial asthma (BA) patients
From: Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy
Gene | Locus | BA | Atopic BA | Nonatopic BA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C/Ca | C/R | R/R | P | C/C | C/R | R/R | P | C/C | C/R | R/R | P | ||
IL1A | +4845G>T (Arg135Ser) | 412 (2.25±0.62)b | 79 (2.22±0.58) | 4 (2.11±0.59) | 0.75 | 291 (2.49±0.52) | 54 (2.45±0.49) | 1 (2.67±0.00) | 0.57 | 121 (1.68±0.48) | 25 (1.74±0.46) | 3 (1.93±0.56) | 0.32 |
IL1B | −511T>C | 123 (2.21±0.59) | 208 (2.25±0.66) | 109 (2.25±0.63) | 0.80 | 91 (2.39±0.54) | 135 (2.55±0.53) | 81 (2.47±0.50) | 0.38 | 32 (1.71±0.44) | 73 (1.69±0.49) | 28 (1.61±0.52) | 0.43 |
−31C>T | 125 (2.22±0.59) | 208 (2.26±0.65) | 107 (2.24±0.63) | 0.92 | 92 (2.40±0.54) | 134 (2.56±0.53) | 80 (2.46±0.50) | 0.49 | 33 (1.71±0.43) | 74 (1.72±0.48) | 27 (1.60±0.52) | 0.40 | |
IL2 | −384T>G | 242 (2.26±0.64) | 234 (2.27±0.59) | 44 (2.18±0.62) | 0.78 | 170 (2.52±0.52) | 160 (2.49±0.50) | 34 (2.37±0.53) | 0.16 | 72 (1.64±0.43) | 74 (1.79±0.49) | 10 (1.54±0.46) | 0.40 |
+114T>G (Leu38Leu) | 162 (2.33±0.64) | 245 (2.22±0.60) | 104 (2.25±0.59) | 0.31 | 121 (2.58±0.50) | 162 (2.47±0.50) | 76 (2.43±0.51) | 0.02 | 41 (1.61±0.42) | 83 (1.74±0.49) | 28(1.75±0.49) | 0.17 | |
ht3 | 222 (2.26±0.61) | 281 (2.27±0.62) | 6 (2.20±0.70) | 0.97 | 155 (2.48±0.50) | 199 (2.50±0.51) | 3 (2.79±0.23) | 0.49 | 67 (1.72±0.50) | 82 (1.70±0.46) | 3 (1.61±0.36) | 0.63 | |
IL3 | +79T>C (Ser27Pro) | 137 (2.19±0.68) | 231 (2.26±0.58) | 101 (2.34±0.62) | 0.18 | 88 (2.49±0.58) | 163 (2.48±0.46) | 76 (2.54±0.54) | 0.58 | 49 (1.65±0.47) | 68 (1.74±0.51) | 25 (1.74±0.40) | 0.36 |
IL4 | −589T>C | 304 (2.28±0.56) | 141 (2.24±0.68) | 19 (2.55±0.83) | 0.32 | 222 (2.48±0.45) | 93 (2.52±0.59) | 16 (2.78±0.65) | 0.08 | 82 (1.73±0.44) | 48 (1.69±0.51) | 3 (1.31±0.52) | 0.27 |
−33T>C | 305 (2.25±0.57) | 146 (2.25±0.67) | 18 (2.54±0.85) | 0.17 | 218 (2.47±0.45) | 98 (2.52±0.58) | 15 (2.78±0.68) | 0.07 | 87 (1.70±0.46) | 48 (1.71±0.48) | 3 (1.31±0.52) | 0.60 | |
IL5RA | −80G>A | 286 (2.27±0.60) | 174 (2.24±0.65) | 39 (2.28±0.54) | 0.87 | 205 (2.48±0.52) | 113 (2.54±0.50) | 32 (2.37±0.53) | 0.72 | 81 (1.73±0.46) | 61 (1.68±0.50) | 7 (1.86±0.35) | 0.95 |
IL8 | −251A>T | 128 (2.19±0.66) | 135 (2.22±0.63) | 49 (2.05±0.65) | 0.37 | 82 (2.45±0.61) | 92 (2.48±0.49) | 28 (2.38±0.59) | 0.59 | 46 (1.73±0.44) | 43 (1.67±0.55) | 21 (1.60±0.43) | 0.29 |
+396G>T | 183 (2.27±0.63) | 194 (2.26±0.63) | 76 (2.18±0.61) | 0.30 | 123 (2.53±0.54) | 139 (2.48±0.51) | 51 (2.45±0.50) | 0.31 | 60 (1.74±0.41) | 55 (1.70±0.57) | 25 (1.63±0.40) | 0.36 | |
+781T>C | 237 (2.26±0.62) | 177 (2.23±0.63) | 49 (2.23±0.64) | 0.39 | 160 (2.50±0.54) | 124 (2.47±0.49) | 37 (2.47±0.53) | 0.57 | 77 (1.74±0.43) | 53 (1.66±0.56) | 12 (1.51±0.38) | 0.12 | |
ht3 (T–G–C) | 254 (2.20±0.65) | 39 (2.09±0.61) | 2 (2.01±0.53) | 0.44 | 164 (2.47±0.56) | 23 (2.42±0.43) | 1 (1.63±0.00) | 0.22 | 90 (1.68±0.49) | 16 (1.61±0.49) | 1 (2.38±0.00) | 0.89 | |
IL10 | −1082A>G | 434 (2.25±0.62) | 66 (2.22±0.60) | 2 (2.30±0.22) | 0.66 | 310 (2.48±0.50) | 42 (2.50±0.53) | 2 (2.30±0.22) | 0.86 | 124 (1.68±0.49) | 24 (1.73±0.35) | – | 0.65 |
−592A>C | 220 (2.28±0.59) | 228 (2.21±0.63) | 47 (2.30±0.62) | 0.99 | 161 (2.49±0.48) | 153 (2.47±0.54) | 35 (2.52±0.49) | 0.85 | 59 (1.70±0.48) | 75 (1.68±0.47) | 12 (1.67±0.50) | 0.80 | |
+3930T>C | 481 (2.25±0.61) | 32 (2.19±0.62) | – | 0.97 | 341 (2.48±0.51) | 19 (2.56±0.45) | – | 0.43 | 140 (1.71±0.48) | 13 (1.66±0.41) | – | 0.73 | |
ht2 (A–C–C–T) | 268 (2.26±0.60) | 195 (2.21±0.63) | 27 (2.31±0.68) | 0.74 | 190 (2.49±0.49) | 135 (2.45±0.53) | 20 (2.55±0.51) | 0.97 | 78 (1.71±0.46) | 60 (1.67±0.47) | 7 (1.60±0.65) | 0.50 | |
ht4 (G–C–C–T) | 451 (2.24±0.62) | 39 (2.25±0.55) | – | 0.55 | 318 (2.48±0.50) | 27 (2.44±0.55) | – | 0.68 | 133 (1.67±0.48) | 12 (1.84±0.26) | – | 0.23 | |
