Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzymopathy among Southeast Asians. We studied G6PD mutations in 108 migrant Cambodian laborers in Chanthaburi province and cord blood samples from 107 Cambodian newborns at Buriram Hospital. Thirty-one (26.1%) of 119 Cambodian males and three of 96 (3.1%) females were G6PD deficient and were assayed for G6PD mutations. G6PD Viangchan (871G>A) was identified in most G6PD-deficient Cambodians (28 of 34; 82.4%); G6PD Union (1360C>T) and G6PD Coimbra (592C>T) was found in one case each. We concluded that G6PD Viangchan (871G>A) was the most common mutation among Cambodians. This finding is similar to G6PD-deficient Thais and Laotians, suggesting a common ancestry of people from these three countries.
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Acknowledgements
We thank Dr. Petcharat Kittiwatanasarn for her assistance in collecting cord blood samples at Buriram Hospital and Dr. Chatchai Sawasdichai for his assistance in collection blood samples at the blood bank, Phrapokklao Hospital. This research was supported by Ministry of University Affairs Funds.
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Louicharoen, C., Nuchprayoon, I. G6PD Viangchan (871G>A) is the most common G6PD-deficient variant in the Cambodian population. J Hum Genet 50, 448–452 (2005). https://doi.org/10.1007/s10038-005-0276-2
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DOI: https://doi.org/10.1007/s10038-005-0276-2
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