Abstract
Dent’s disease (DD) involves nephrocalcinosis, urolithiasis, hypercalciuria, LMW proteinuria, and renal failure in various combinations. Males are affected. It is caused by mutations in the chloride channel CLCN5 gene. It has been suggested that DD is underdiagnosed, occurring in less overt forms, apparently without family history. A possible approach to this problem is to search for CLCN5 mutations in patients who may have a high prevalence of mutations: end-stage renal disease (ESRD) patients with previous calcium, struvite, or radio-opaque (CSR) stones. We looked for CLCN5 mutations in 25 males with ESRD–CSR stones selected from all of the patients (1,901 individuals, of which 1,179 were males) of 15 dialysis units in the Veneto region. One DD patient had a new DD mutation (1070 G>T) in exon 7. The new polymorphism IVS11–67 C>T was detected in intron 11 in one patient and one control. We also found 28 females with ESRD and stone history, and seven more males with ESRD and non-CSR stones. The prevalence of stone formers among dialysis patients in our region was 3.2%, much lower than the prevalence observed in older studies. Struvite stones continue to play a major role in causing stone-associated ESRD .
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Acknowledgments
The Veneto Collaborative Study Group on Dent’s Disease comprised the following members: E. De Paoli Vitali, Belluno; G. Bonadonna, Camposampiero; C. Cascone, Castelfranco Veneto, and Treviso; V. Goepel, Chioggia; G. Meneghel, Dolo; J. Nachtigal, F. Antonucci, Feltre; A. Fracasso, Mestre; P. Conz, C. Catalano, Monselice; A. Antonello, A. D’Angelo, L. Citron, F. Nalesso, R. Zagatti, U. Vertolli, Padova (two centers); M. Piva, Rovigo; T. Teodori, S. Donà di Piave; M. Nordio, Venezia; R. Dell’Aquila, Vicenza, and G. Gambaro, A. Lupo, Verona. This study was supported by the Italian Ministry of the University, program Cofin 40%, No. 2002062925-003, year 2002, and by Regione Veneto, Ricerca Sanitaria Finalizzata, Malattie Rare, year 2000 (No. 798/03/98).
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Preliminary data from this paper were presented at the 10th International Symposium on Urolithiasis, Hong Kong, May 25–28, 2004, and published in abstract form in Urol Res 32:152–153, 2004
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Tosetto, E., Graziotto, R., Artifoni, L. et al. Dent’s disease and prevalence of renal stones in dialysis patients in Northeastern Italy. J Hum Genet 51, 25–30 (2006). https://doi.org/10.1007/s10038-005-0317-x
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DOI: https://doi.org/10.1007/s10038-005-0317-x
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