Abstract
The scavenger receptor class B type 1 (SCARB1) gene is a key component in the reverse cholesterol transport pathway and thus plays an important role in lipid metabolism. Studies suggest that the SCARB1 gene may contribute to variation in plasma lipid levels at fasting; however, the results have been inconsistent, and it is unclear whether SCARB1 may also influence lipid response to dietary and pharmacologic interventions. In this study, we examined genetic variation in the SCARB1 gene in participants of the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study for associations with basal lipid levels, changes in lipid measures after dietary fat intake, and fenofibrate treatment. We found that the exon 1 variant SCARB1_G2S was significantly associated with postfenofibrate change for triglycerides (TG) (P = 0.004). Subjects bearing SCARB1_G2S minor allele A tend to have higher responsiveness to fenofibrate in lowering TG. In summary, our study suggested that the SCARB1 gene may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention.
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Acknowledgments
We thank the families for their participation in this research. This work was supported by the National Institute of Health Heart, Lung, and Blood Institute grant U 01 HL72524, genetic and environmental determinants of triglycerides. We acknowledge Abbott Laboratories (Abbott Park, IL, USA) for their supply of study medication for this project. Dr. David B. Allison is supported by NIH grant 3P30DK056336. Dr. Kui Zhang is supported by NIH grant R01GM74913.
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We declare that we have no duality or conflict of interest.
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Liu, Y., Ordovas, J.M., Gao, G. et al. The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions. J Hum Genet 53, 709–717 (2008). https://doi.org/10.1007/s10038-008-0302-2
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DOI: https://doi.org/10.1007/s10038-008-0302-2
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