Abstract
The aim of this study was to evaluate the relationship between smoking, alcohol drinking and genetic polymorphism of the growth hormone 1 gene (GH1) T1663A with reference to colorectal cancer. We conducted a case–control study with 315 cases of colorectal cancer and 438 population-based controls in the Jiangsu Province, China. GH1 T1663A genotypes were identified using PCR–RFLP (restriction fragment length polymorphism) methods. Information on smoking and drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of T/T and A/A genotypes was significantly different between controls and cases (χ2MH=3.877, P=0.049). Compared with the GH1 T/T genotype, the A/A genotype was at a decreased risk of developing colorectal cancer (sex-, age-, body mass index-, smoking- and alcohol drinking-adjusted OR=0.56, 95% confidence interval: 0.34–0.90). Smoking was not associated with the risk of colorectal cancer, whereas alcohol drinking was associated with an increased risk of colorectal cancer. Among nonsmokers or nondrinkers, individuals who had the GH1 A/A genotype were at a decreased risk of developing colorectal cancer compared with individuals who had the GH1 T allele. These results show that the GH1 T1663A A/A genotype can decrease the risk for colorectal cancer.
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Acknowledgements
This study was supported in part by a Grant-in Aid for International Scientific Research; Special Cancer Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan, No. 11 137 311; and Major International (Regional) Joint Research Projects from the National Natural Science Foundation of China (NSFC), No. 30 320 140 461. We thank the staff of the Huaian City Municipal Hospital and Public Health Center of Huaian and Jintan Cities for their assistance in data collection.
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Gao, CM., Gong, JP., Wu, JZ. et al. Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer. J Hum Genet 55, 163–166 (2010). https://doi.org/10.1038/jhg.2010.3
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DOI: https://doi.org/10.1038/jhg.2010.3
