Abstract
We examined the association of schizophrenia (SCZ) and dihydropyrimidinase-like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.
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Acknowledgements
We sincerely thank the patients and healthy volunteers for their participation in this study. We express our gratitude to Dr Ryoko Ishihara, Yukako Nakamura, Itaru Kushima, Tomoko Shiino, Eri Yara, Tomo Okochi and Yasuhisa Fukuo for their technical assistance. Funding for this study was provided by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Ministry of Health, Labor and Welfare of Japan; Grant-in-Aid for Scientific Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan; The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes and the Core Research for Evolutional Science and Technology.
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Koide, T., Aleksic, B., Ito, Y. et al. A two-stage case–control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet 55, 469–472 (2010). https://doi.org/10.1038/jhg.2010.38
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DOI: https://doi.org/10.1038/jhg.2010.38
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