Table 1 Association of 1q43 SNPs with uterine fibroids and BMI in European Americans enrolled in the NIEHS study

From: Confounding by linkage disequilibrium

     

Uterine fibroids (UL), Pa

BMI, Pb

Obs

SNP

Inter-SNP distance, base pair

Gene

Function

BMI adjusted

BMI unadjusted

UL adjusted

UL unadjusted

375

rs4391653

 

RGS7

Intronic

0.0063

 

0.0272

0.0245

416

rs4290050

57 222

RGS7

Intronic

 

0.0078

  

417

rs4378194

19

RGS7

Intronic

 

0.0153

  

418

rs2815842

229

RGS7

Intronic

 

0.0143

  

644

rs2994976

225 065

RGS7-FH

Intergenic

 

0.0482

  

651

rs3014580

4859

RGS7-FH

Intergenic

 

0.0457

  

656

rs2994979

4046

Downstream FH

Intronic

0.0050

0.0800

  

658

rs11586971

1123

Downstream FH

Intronic

0.0050

   

659

rs12754512

51

Downstream FH

Intronic

0.0050

   

661

rs2994981

1967

downstream FH

Intronic

0.0045

   

662

rs12566016

460

downstream FH

Intronic

0.0045

   

663

rs10926494

204

downstream FH

Intronic

0.0017

   

673

rs2144

7176

Downstream FH

Intronic

0.0014

   

943

rs10802996

365 915

EXO1

5′-UTR

 

0.0075

  

948

rs4149864

58 417

EXO1-MAP1LC3C

Intergenic

0.0724

0.0274

  

987

rs4150028

29 371

EXO1-MAP1LC3C

Intergenic

0.0193

   

1037

rs3845563

545 213

PLD5

Intronic

 

0.0016

  

1292

rs10926736

10 854

PLD5

Intronic

 

0.0019

  

1320

rs7531009

7558

PLD5

Intronic

 

0.0064

0.0098

0.0099

1335

rs10926756

208 978

Far upstream PLD5

Intergenic

 

0.0015

  

1340

rs1039534

1531

Far upstream PLD5

Intergenic

 

0.0047

  

1587

rs10754775

160

Far upstream PLD5

Intergenic

 

0.0047

  

1600

rs6673294

1757

Far upstream PLD5

Intergenic

 

0.0043

  

1602

rs10803075

493

Far upstream PLD5

Intergenic

 

0.0053

  

1603

rs6679445

494

Far upstream PLD5

Intergenic

 

0.0014

  
  1. Abbreviations: BMI, body mass index; FH, fumarate hydratase; PDL5, phospholipase D member 5; SNP, single nucleotide polymorphism; UL, uterine leiomyoma.
  2. aLogistic regression models adjusted for covariates (age, age at menarche, parity and physical activity).
  3. bGeneral linear models adjusted for the effects of age and physical activity. Note that only SNPs that showed significant levels of association with either the uterine fibroid or the BMI outcome or with both outcomes are shown.
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