Abstract
Human APOBEC3H (A3H) is a member of APOBEC cytidine deaminase family intensively constraining the HIV-1 replication. A3H is known to be polymorphic with different protein stability and anti-HIV-1 activity in vitro. We recently reported that A3H haplotypes composed of two functional polymorphisms, rs139292 (N15del) and rs139297 (G105R), were associated with the susceptibility to HIV-1 infection in Japanese. To confirm the association of A3H and HIV-1 infection in another ethnic group, a total of 241 HIV-1-infected Indian individuals and ethnic-matched 286 healthy controls were analyzed for the A3H polymorphisms. The frequency of 15del allele was high in the HIV-1-infected subjects as compared with the controls (0.477 vs 0.402, odds ratio (OR)=1.36, P=0.014). Haplotype analysis showed that the frequencies of 15del–105R was high (0.475 vs 0.400, OR=1.36, permutation P=0.037) in the HIV-1-infected subjects, confirming the association of A3H polymorphisms with the susceptibility to HIV-1 infection.
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Acknowledgements
We thank Ms N Ohkubo and Y Ueda for their technical assistance. This work was supported in part by research grants from the Ministry of Health, Labor and Welfare, Japan; Grant-in-Aids for Scientific research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan; a grant from the Indian Council of Medical Research; and by grants for India–Japan Cooperative Science Program from Japan Society for the Promotion of Science (JSPS), Japan and Department of Science and Technology (DST). This work was also supported by a support for women researchers from the Tokyo Medical and Dental University and the Joint Usage/Research Program of Medical Research Institute, Tokyo Medical and Dental University.
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Naruse, T., Sakurai, D., Ohtani, H. et al. APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population. J Hum Genet 61, 263–265 (2016). https://doi.org/10.1038/jhg.2015.136
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DOI: https://doi.org/10.1038/jhg.2015.136
