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Preferential association of aldosterone synthase gene polymorphism with central blood pressure and wave reflections in hypertensive individuals

Journal of Human Hypertension volume 24, pages 291–299 (2010)Cite this article

Abstract

In hypertensive humans, the CC genotype of the aldosterone synthase gene polymorphism (ASGP) CYP11B2 (C-344T variant) is associated with increased aortic stiffness. Whether ASGP is also associated with altered central (carotid) wave reflections has never been investigated. After 1-month wash-out period, 124 hypertensive individuals were submitted to measurements of brachial and carotid systolic blood pressure (SBP), aortic pulse wave velocity (PWV) and wave reflections, using the carotid augmentation index (CAI) determined from pulse wave analysis. Two age- and sex-adjusted models of the impact of ASGP were analysed. Comparing the ASGP-CC with ASGP-TT and -TC genotypes, the former had significantly stronger intergroup correlation coefficients for age or CAI vs heart rate relationships (P=0.008; P=0.02). Stepwise multiple regressions showed that carotid SBP was independently influenced by PWV and CAI, but only in individuals with the CC (P=0.0002; P=0.03) and TC genotypes (P=0.0004; P=0.004). Those associations were not, or only weakly, observed using the brachial artery SBP model. In conclusion, this study showed that, in hypertensive individuals, ASGP is not directly associated with the SBP level, but rather independently with its two main determinants, central PWV and wave reflections. The result was observed only for CC and TC genotypes. Such findings are observed when central, but not brachial, haemodynamic measurements are performed.

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Acknowledgements

This study was performed with the help of INSERM (Institut de la Santé et de la Recherche Médicale), Paris and GPH-CV (Groupe de Pharmacologie et d'Hémodynamique Cardiovasculaire). We thank Mrs Debouté for excellent assistance.

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Authors and Affiliations

  1. Université Paris Descartes,

    J Blacher, J-M Lacombe & M E Safar

  2. Assistance Publique-Hôpitaux de Paris,

    J Blacher, J-M Lacombe & M E Safar

  3. Centre de Diagnostic et de Thérapeutique, Hôtel-Dieu, Paris, France

    J Blacher, J-M Lacombe & M E Safar

  4. INSERM, U961, Nancy, France

    A Kakou

  5. Henri Poincaré University, INSERM, U684, Nancy, France

    A Kakou

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  1. J Blacher
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  2. A Kakou
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  3. J-M Lacombe
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  4. M E Safar
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Correspondence to M E Safar.

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Blacher, J., Kakou, A., Lacombe, JM. et al. Preferential association of aldosterone synthase gene polymorphism with central blood pressure and wave reflections in hypertensive individuals. J Hum Hypertens 24, 291–299 (2010). https://doi.org/10.1038/jhh.2009.59

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