Table 3 Holter ECG abnormalities (frequency >3%; safety set)
Holter finding | Placebo, N=53 | ACT-280778, N=52 | Amlodipine, N=54 | |||
|---|---|---|---|---|---|---|
n | % | n | % | n | % | |
Overall | ||||||
Total subjects with at least one Holter finding | 39 | 73.6 | 43 | 82.7 | 40 | 74.1 |
Total number of Holter findings | 64 | 84 | 69 | |||
Supraventricular tachycardia | 10 | 18.9 | 15 | 28.8 | 10 | 18.5 |
Multifocal ventricular extrasystoles | 8 | 15.1 | 12 | 23.1 | 13 | 24.1 |
Ventricular extrasystoles | 8 | 15.1 | 12 | 23.1 | 9 | 16.7 |
Unifocal ventricular extrasystoles | 12 | 22.6 | 11 | 21.2 | 14 | 25.9 |
Supraventricular extrasystoles | 5 | 9.4 | 10 | 19.2 | 3 | 5.6 |
Sinus bradycardia | 1 | 1.9 | 6 | 11.5 | — | |
Frequent supraventricular extrasystoles | 6 | 11.3 | 5 | 9.6 | 3 | 5.6 |
Sinus arrhythmia | 5 | 9.4 | 4 | 7.7 | 6 | 11.1 |
Sinus tachycardia | — | 2 | 3.8 | 5 | 9.3 | |
Sinus pauses | — | 2 | 3.8 | — | ||
Type I second-degree AV block | 2 | 3.8 | 1 | 1.9 | 1 | 1.9 |
Ventricular tachycardia | 2 | 3.8 | — | 4 | 7.4 | |
