Table 5 Haplotypes in AdipoQ and BP responses to dietary intervention

Haplotype sequence	Haplotype frequency	SBP response		DBP response		MAP response
		Z	P-value	Z	P-value	Z	P-value
Low-sodium intervention
Haplotype1 (rs16861194–rs182052)
AG	0.564	1.446	0.148	0.304	0.761	0.807	0.420
AA	0.295	−1.058	0.290	−1.254	0.210	−1.289	0.197
GA	0.138	−0.688	0.492	1.078	0.281	0.461	0.645
Haplotype2 (rs822394–rs12495941)
CG	0.462	−1.354	0.176	−0.109	0.914	−0.63	0.529
CT	0.406	1.207	0.227	0.776	0.438	1.048	0.295
AG	0.132	0.126	0.900	−1.06	0.289	−0.583	0.560
High-sodium intervention
Haplotype1
AG	0.564	0.137	0.891	−0.701	0.484	−0.457	0.647
AA	0.295	0.4	0.689	0.272	0.786	0.339	0.735
GA	0.138	−0.712	0.477	0.819	0.413	0.342	0.732
Haplotype2
CG	0.462	0.346	0.730	0.959	0.338	0.814	0.416
CT	0.406	−0.512	0.609	0.045	0.964	−0.159	0.874
AG	0.132	0.245	0.807	−1.691	0.091	−1.07	0.285
High-sodium plus potassium supplementation intervention
Haplotype1
AG	0.564	1.408	0.159	−0.302	0.763	0.357	0.721
AA	0.295	−0.355	0.722	0.947	0.344	0.539	0.590
GA	0.138	−1.689	0.091	−0.737	0.461	−1.158	0.247
Haplotype2
CG	0.462	−0.642	0.521	0.672	0.502	0.223	0.824
CT	0.406	−0.198	0.843	−0.718	0.473	−0.6	0.549
AG	0.132	1.4	0.161	0.059	0.953	0.667	0.504

Abbreviations: BP, blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; SBP, systolic blood pressure; SNP, single nucleotide polymorphism.
Z indicates test statistic for family-based association test; P-values are corrected for multiple testing (false discovery rate <0.05).

Quick links

Search