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Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates

Journal of Perinatology volume 33, pages 619–621 (2013)Cite this article

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Abstract

Objective:

To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates.

Study Design:

Retrospective cohort study of all low-dose (3–5 μg kg−1 per min) dopamine infusions >24-h duration in neonates ⩽1500 g and ⩽32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP.

Result:

We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg−1 h−1 increase in UOP (P<0.001) and a 1.3 ml kg−1h−1 increase when baseline UOP was <1.5 ml kg−1 h−1 (P<0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake.

Conclusion:

Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.

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Authors and Affiliations

  1. Department of Pediatrics, Duke University Medical Center, Durham, NC, USA

    J L Crouchley, P B Smith, C M Cotten, C D Hornik, R N Goldberg, J W Foreman & J L Wynn

Authors
  1. J L Crouchley
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  2. P B Smith
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  3. C M Cotten
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  4. C D Hornik
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  5. R N Goldberg
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  6. J W Foreman
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  7. J L Wynn
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Correspondence to C M Cotten.

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The authors declare no conflict of interest.

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Crouchley, J., Smith, P., Cotten, C. et al. Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates. J Perinatol 33, 619–621 (2013). https://doi.org/10.1038/jp.2013.20

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