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Perinatal outcomes in singleton and twin pregnancies following first-trimester bleeding

Journal of Perinatology volume 34, pages 673–676 (2014)Cite this article

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Abstract

Objective:

To investigate associations between first-trimester bleeding and perinatal outcomes.

Study design:

Registry-based survey of the period 2002 through 2010. Pregnancies with versus without first-trimester bleeding were compared using Student’s t- and χ2-test. Multivariable logistic regression was used to control for potential confounders.

Result:

9924 singleton and 275 twin pregnancies with first-trimester bleeding, and 160 099 singleton and 2710 twin pregnancies without bleeding were included. Bleeding increased the risk of preterm birth in singletons (odds ratio 1.48; 95% confidence interval 1.38–1.60). Risks were also increased for preterm premature rupture of membranes, abruption, previa, stillbirth and congenital anomalies, with a reduced risk of preeclampsia. The differences remained significant after adjustment for confounders. In twin pregnancies, bleeding was not significantly associated with prematurity (odds ratio 1.04; 95% confidence interval 0.81–1.34), nor with other outcomes.

Conclusion:

In singletons, but not in twins, the risk of perinatal complications is significantly increased after first-trimester bleeding.

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Authors and Affiliations

  1. Department of Perinatology, Division of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia

    M Lucovnik, N Tul & I Verdenik

  2. Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, affiliated with the Hadassah-Hebrew University school of Medicine, Jerusalem, Israel

    I Blickstein

Authors
  1. M Lucovnik
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  2. N Tul
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  3. I Verdenik
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  4. I Blickstein
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Correspondence to M Lucovnik.

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Lucovnik, M., Tul, N., Verdenik, I. et al. Perinatal outcomes in singleton and twin pregnancies following first-trimester bleeding. J Perinatol 34, 673–676 (2014). https://doi.org/10.1038/jp.2014.74

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