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Validation of noninvasive hemoglobin measurement by pulse co-oximeter in newborn infants

Journal of Perinatology volume 35, pages 617–620 (2015)Cite this article

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Abstract

Objective:

To describe the accuracy of noninvasive hemoglobin (Hb) obtained with pulse co-oximeter (SpHb) compared with total Hb (tHb) from laboratory co-oximeter in neonates.

Study design:

Neonates with birth weight (BW) <3000 g admitted to LAC+USC Medical Center neonatal intensive care unit were included. SpHb was recorded using Masimo Radical-7 and compared with tHb. A total of three data sets were obtained for each patient. Regression analysis and Bland–Altman analysis were performed.

Result:

Sixty-one patients (mean±s.d., BW 1177±610 g and gestational age 28.7±3.9 weeks) were enrolled. The mean tHb value was 13.9±2.0 g dl−1 and the mean SpHb was 14.0±2.0 g dl−1. There was a moderately positive correlation between SpHb and tHb (r=0.66, P<0.001) with a bias and precision of −0.09±1.67 g dl−1. Data from a subgroup of infants with gestational age ⩽32 weeks (52/61 patients) were analyzed, and the correlation coefficient was moderately positive (r=0.69, P<0.001) with a bias and precision of −0.23±1.60 g dl−1.

Conclusion:

Our results suggest that noninvasive SpHb may be considered as an adjunct to invasive tHb measurements in newborn infants <3000 g especially in preterm infants ⩽32 weeks of gestation.

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Acknowledgements

We thank Masimo Corporation for providing the probes used in this study; however, they did not participate in the study design, analysis and interpretation of the data, or the preparation or approval of the manuscript. We also thank the respiratory therapists, neonatologists, neonatal fellows and the staff of LAC+USC Neonatal Intensive Care Unit for their cooperation with the study.

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Authors and Affiliations

  1. Division of Neonatal Medicine, Department of Pediatrics, LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA

    C Nicholas, S Sardesai, M Durand, R Ramanathan & R Cayabyab

  2. Division of Neonatal Medicine, Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    C Nicholas, R George & R Ramanathan

Authors
  1. C Nicholas
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  2. R George
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  3. S Sardesai
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  4. M Durand
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Corresponding author

Correspondence to C Nicholas.

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Competing interests

The authors declare no conflict of interest.

Additional information

This work was presented in part at the Pediatric Academic Societies annual meeting, Washington, DC, May 2013.

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Nicholas, C., George, R., Sardesai, S. et al. Validation of noninvasive hemoglobin measurement by pulse co-oximeter in newborn infants. J Perinatol 35, 617–620 (2015). https://doi.org/10.1038/jp.2015.12

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