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Sustained lung inflation in late preterm infants: a randomized controlled trial

Journal of Perinatology volume 36, pages 443–447 (2016)Cite this article

Subjects

Abstract

Objective:

To assess the need for respiratory support in late preterm infants treated with sustained lung inflation (SLI) at birth.

Study design:

In this controlled trial, we randomly assigned infants born at 34+0 to 36+6 weeks of gestation to receive SLI (25 cmH2O for 15 s) at birth, followed by continuous positive airway pressure (CPAP) or assistance according to the recommendations of the American Academy of Pediatrics. The primary outcome was the need for any type of respiratory support. The secondary outcomes included neonatal intensive care unit (NICU) admission for respiratory distress and length of stay. The risk ratios (RRs) and 95% confidence intervals (CIs) of the outcomes were calculated for the SLI group in reference to the control group.

Results:

A total of 185 infants were enrolled: 93 in the SLI group and 92 in the control group. No difference was found in the need for any type of respiratory support between the infants treated with SLI and the control group (10.6 vs 8.7%, RR 1.24, 95% CI 0.51 to 2.99). The NICU admission for respiratory distress and the length of stay did not differ between the groups.

Conclusion:

Providing SLI at birth in late preterm infants does not affect their need for respiratory support.

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Acknowledgements

The authors have no financial relationships relevant to this article to disclose. No honorarium, grant or other form of payment was given to any of the authors to produce the manuscript.

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Authors and Affiliations

  1. Department of Clinical Sciences and Community Health, NICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy

    D Mercadante, M Colnaghi, V Polimeni, E Ghezzi, M Fumagalli & F Mosca

  2. Epidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy

    D Consonni

Authors
  1. D Mercadante
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  2. M Colnaghi
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  3. V Polimeni
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  4. E Ghezzi
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  5. M Fumagalli
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  6. D Consonni
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  7. F Mosca
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Correspondence to D Mercadante.

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Mercadante, D., Colnaghi, M., Polimeni, V. et al. Sustained lung inflation in late preterm infants: a randomized controlled trial. J Perinatol 36, 443–447 (2016). https://doi.org/10.1038/jp.2015.222

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  • DOI: https://doi.org/10.1038/jp.2015.222

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