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Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice

Abstract

Imaging studies that use rodents sometimes involve intraperitoneal administration of pharmacological compounds. To facilitate such studies, the authors developed a simple and easily mastered technique for placing an intraperitoneal catheter in a conscious mouse. This technique eliminates the need to remove the animal from the scanner to administer a drug through the intraperitoneal route.

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Figure 1
Figure 2: We securely hold the animal in one hand to expose the animal's ventral surface.
Figure 3: We secure the mouse in the MRI restraining device in the prone position.

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Acknowledgements

This work was supported by the Department of Veterans Affairs. We thank Ky Dehlinger, DVM for carrying out the necropsies.

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Correspondence to Eilis Boudreau.

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The authors declare no competing financial interests.

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Boudreau, E., Chen, G., Li, X. et al. Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice. Lab Anim 39, 23–25 (2010). https://doi.org/10.1038/laban0110-23

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