Figure 1 | Laboratory Investigation

Figure 1

From: Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas

Figure 1

The levels of MMP7 in the cis-Apc/Smad4 polyps. (a) Expression of MMP7 mRNA determined by RT-PCR. Total RNA was prepared from the intestinal tissues of normal C57BL/6 mice (wild type) or polyps of ApcΔ716 and cis-Apc/Smad4 mice. (b) Expression of MMP7 protein determined by western blotting. Open and closed arrowheads indicate pro- and active-MMP7, respectively. (c) Intestinal polyps (top) and normal tissues (bottom) of ApcΔ716 (left) and cis-Apc/Smad4 (right) mice stained for MMP7. Insets show higher magnifications of the boxed areas. Scale bars show 200 and 100 μm (inset) in top panels, and 200 and 10 μm (inset) in bottom panels.

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