Figure 2 | Laboratory Investigation

Figure 2

From: Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas

Figure 2

Effects of MMP7-deficiency on tumor formation in the cis-Apc/Smad4 mice. (a) Expression of MMP7 mRNA (left) and protein (right) in the intestinal polyps (P) and normal tissues (N) from MMP7-intact (+/+) and knockout (−/−) cis-Apc/Smad4 mice. (b) Total number of the intestinal polyps in the MMP7-intact (+/+) and knockout (−/−) cis-Apc/Smad4 mice. Results show a mean number of polyps/mouse±s.d. (n=9). P<0.001. (c) Size distribution of the intestinal polyps. Polyps were classified according to their diameters in millimeters. Results are shown as percentages for the respective size classes (n=9). Φ indicates polyp diameter (mm). (d) Intestinal tumors in the cis-Apc/Smad4 and cis-Apc/Smad4 Mmp7−/− mice stained with H&E. Scale bars show 200 μm.

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