Figure 7
Genome-wide pattern of LOH identified by WOHGM in a single cystectomy. (a) Three-dimensional display of the LOH distribution patterns in a single cystectomy specimen. The vertical axis represents sex-averaged recombination-based chromosomal maps with positions of hypervariable markers and their chromosomal location. The shaded blocks represent areas of bladder mucosa with LOH as they relate to the development of bladder cancer from in situ neoplasia, represented by a histologic map of the cystectomy shown at the bottom. The allelic patterns of markers in mucosal samples were compared to their patterns in peripheral blood lymphocytes of the same patient. The histologic map code is the same as in Figure 3. (b) Clonal losses associated with expansion of in situ neoplasia. Chromosomal regions exhibiting allelic losses associated with early and late phases of bladder neoplasia were identified as described in Figure 3.
