Figure 4

Effect of a single dose of TCPOBOP (3 mg/kg) to intact young mice on LI (a), liver weight (b) and total liver DNA content (c). Mice were killed 3 days after the administration of TCPOBOP. All mice were given BrdU (1 mg/ml) in drinking water until the time of killing. Administration of TCPOBOP resulted in an increased LI, larger liver mass and corresponding increase in total hepatic DNA content when compared with controls. Results are expressed as means±s.e. of five mice per group. P<0.001.