Figure 4 | Laboratory Investigation

Figure 4

From: Induction of cytomegalovirus-infected labyrinthitis in newborn mice by lipopolysaccharide: a model for hearing loss in congenital CMV infection

Figure 4

Distribution of IE1-positive cells in the labyrinths in the MCMV-i.p.-infected mice with i.c. injections of LPS (a) and in the MCMV-i.c.-infected mice (b). In both groups, newborn mice were infected and killed 6 days after infection. After immunohistochemical staining, IE1-positive cells were counted in the portions of the labyrinths, such as cochlear nerve (CN), mesenchymal (M) region, including spiral ganglia (SG), scala tympani (ST), scala vestibuli (SV), spiral limbus (SL) and scala media (SM). The number of IE1-positive cells was expressed as the average number±s.d. per labyrinth. Virus-infected cells were counted in three sections per each animal and at least eight animals were assessed. *P<0.05 by Student's t-test. #Only two cases had positive cells in this lesion.

Back to article page