Figure 3 | Laboratory Investigation

Figure 3

From: Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development

Figure 3

Expression of biliary-associated transcription factor HNF3β in hepatocytes, in cases of late-stage primary biliary cirrhosis (PBC) and chronic biliary obstruction (BO). (a–f) Immunohistochemical staining of HNF3β and CK19 in normal vs PBC and BO. Hepatocytes are negative whereas bile ducts are positive for HNF3β in normal adult liver (a) however, hepatocytes stain positive for HNF3β in PBC (b) and BO (c). In normal adult liver, hepatocytes are negative (d) whereas bile ducts are positive for CK19 in PBC (e) and BO (f). Arrows indicate positive staining. BD, bile duct; CV, central vein; PV, portal vein. (g) Quantitative analysis of HNF3β immunostaining in the liver diseases in hepatocytes vs BEC. The bars indicate the mean and standard error from cell counts of separate cases, each disease from a number of separate specimens as described in ‘Materials and Methods’. Blue, hepatocytes; red, biliary cells.

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