Figure 2 | Laboratory Investigation

Figure 2

From: Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells

Figure 2

Correlations among VEGF, VEGF receptors and microvessel density. (a) Duplicate histocores taken for separate areas within 300 RCCs were analyzed for VEGF-R1 expression within the tumor mask. AQUA scores for VEGF-R1 expression for the first vs the second histocore are shown, and associations are expressed using Spearman's ρ. (b) Similarly, vessel area, expressed as the area covered by CD34 within the tumor demonstrates strong core-to-core correlation. (c) Expression of VEGF-R3 within the vessel area of matched histocores also shows strong correlation. (d) Spearman's ρ correlation coefficients were determined for all combinations of VEGF, receptors and microvessel density. Direct correlations are shown in red, indirect correlations are in green. The intensity of color in each square represents the strength of the association. Correlations with a P-value of less than 0.0004 (corresponding to the Bonferroni correction for 112 multiple tests at an α of 0.05) are highlighted in yellow. Note that for ease of reading scores are represented twice.

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