Table 1 VEGF and VEGF receptor expression in RCC

From: Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells

 

AQUA score

Nuclear grade

Stage

 

Mean

s.d.

1–2

3–4

P-value

I–II

III–IV

P-value

Tumor

 VEGF

36.9

23.6

34.8

41.0

0.0260

36.4

38.1

0.5608

 VEGF-R1

43.8

21.0

40.3

50.5

<0.0001

42.7

56

0.1658

 VEGF-R2

66.5

31.4

63.6

72.4

0.0145

64.1

71.2

0.0486

 VEGF-R3

32.7

12.0

31.5

35.0

0.0094

31.9

34.3

0.0883

Tumor vessel

 VEGF-R1

10.3

5.8

9.9

11.2

0.0538

10.0

10.9

0.1854

 VEGF-R2

21.6

6.2

22.2

21.3

0.2863

21.7

21.6

0.9368

 VEGF-R3

14.6

7.8

13.9

15.8

0.0372

13.6

16.7

0.0006

 Vessel area

3.6

3.4

4.1

2.8

0.0020

3.7

3.6

0.6548

Normal

 VEGF

36.2

17.8

37.5

33.0

0.0478

37.4

33.5

0.0921

 VEGF-R1

33.4

13.9

34.1

32.0

0.2320

33.5

33.1

0.8014

 VEGF-R2

61.3

19.8

62.2

59.9

0.3637

63.3

57.2

0.0128

 VEGF-R3

27.1

10.6

27.1

27.3

0.9091

27.1

27.0

0.9153

Normal vessel

 VEGF-R1

8.8

7.9

8.9

8.6

0.7386

9.0

8.3

0.4838

 VEGF-R2

16.3

5.4

16.5

16.1

0.6045

16.4

16.2

0.8102

 VEGF-R3

9.0

4.8

9.0

9.0

0.9783

8.5

9.9

0.0278

 Vessel area

5.5

2.9

5.3

5.6

0.4078

5.8

5.0

0.0307

  1. AQUA, automated quantitative analysis; VEGF, vascular endothelial growth factor.
  2. Associations with P<0.05 are bolded.
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