Figure 7
From: Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice
Effect of LPS and SAMe treatment on serum ALT levels and hepatic mRNA levels of cytokines. (a) Serum ALT levels were measured as described in ‘Materials and Methods’. *P<0.001 vs control group, †P<0.01 vs LPS group, n=4–14 per group. (b) Hepatic TNFα mRNA levels were measured using real-time PCR as described in ‘Materials and Methods’. (c) Hepatic interleukin (IL)-1β mRNA levels were measured using real-time PCR. (d) Hepatic iNOS and IL-10 mRNA levels were measured using real-time PCR. SAMe pretreatment group is labeled SAMe+LPS and SAMe post-treatment group is labeled LPS+SAMe. For cytokine mRNA levels, *P<0.01 vs control group and **P<0.05 vs control group, †P<0.05 vs LPS group, n=4–8 per group.
