Figure 5 | Laboratory Investigation

Figure 5

From: FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration

Figure 5

The administration of FTY720 suppresses antibody-induced joint inflammation in mice. (a–c) B6 and CD1d−/− mice were injected with or without FTY720 in a K/BxN serum transfer model. (Panel a) Ankle thickness in mice and their clinical scores. (*P<0.05 and **P<0.01, B6 mice vs B6 mice+FTY720). (Panel b) IL-4, IFN-γ, TGF-β1 and (panel c) Vα14-Jα18 TCR expression was measured by real-time PCR in the joint tissues of FTY720-treated B6 and CD1d−/− mice. (*P<0.05 and **P<0.01, B6 mice vs B6 mice+FTY720, or CD1d−/− mice vs CD1d−/− mice+FTY720). (Panels a–c) The results shown are representative of five independent experiments (n=3 in each group).

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