Figure 3 | Laboratory Investigation

Figure 3

From: Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway

Figure 3

Tat-JBD inhibited the phosphorylation of c-Jun and diminished the increased level of Fas L protein in SNc regions. (a) Effects of Tat peptides on MPTP-induced activation and expression of c-Jun in SNc. Western blot probed with antibodies to phosphorylated c-Jun (p-c-Jun, Ser63/73) and c-Jun. (b) Bands corresponding to p-c-Jun and c-Jun were scanned and the intensities were represented as folds vs saline groups. (c) Effects of Tat peptides on the increases of expression of Fas L and Fas induced by MPTP in SNc. Western blot probed with antibodies to Fas L and Fas. (d) Bands corresponding to Fas L and Fas were scanned and the intensities were represented as folds vs saline groups. Data are expressed as mean±s.d. (n=6). aP<0.05 vs saline; bP<0.05 vs MPTP groups (n=6 mice).

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