Figure 4 | Laboratory Investigation

Figure 4

From: Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway

Figure 4

Effects of Tat-JBD on the altered phosphorylation of Bcl-2 and interactions of Bcl-2 with Bax. (a) Effects of Tat-JBD on the increased phosphorylation of Bcl-2 induced by MPTP in SNc. Western blot probed with antibodies to phosphorylated Bcl-2 (p-Bcl-2, Ser87) and Bcl-2. (b) Bands corresponding to p-Bcl-2 and Bcl-2 were scanned and the intensities were represented as folds vs saline groups. Data are expressed as mean±s.d. (n=6). aP<0.05 vs respective saline, bP<0.05 vs MPTP groups. (c) Co-immunoprecipitation analysis of interactions between Bcl-2 and Bax. (d) Bands corresponding to Bax and Bcl-2 were scanned and the intensities were represented as folds vs saline groups. Data are expressed as mean±s.d. aP<0.05 vs respective saline, bP<0.05 vs MPTP groups (n=6 mice).

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