Figure 6 | Laboratory Investigation

Figure 6

From: Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway

Figure 6

Tat-JBD decreased the activation of caspase-3 in cytosol in SNc regions of MPTP-treated mice. (a) Effects of Tat peptides increased the level of cleaved Caspase3 and cleaved PARP in cytosol-induced MPTP lesion in SNc. Western blot probed with antibodies to cleaved Caspase3 and cleaved PARP. (b) Bands corresponding to cleaved caspase3 and cleaved PARP were scanned and the intensities were represented as folds vs saline control. Data are the mean±s.d. and were expressed as folds vs respective saline. aP<0.05 vs saline control bP<0.05 vs MPTP injection groups (n=6 mice).

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