Figure 5

LPS/GalN-induced activation of p65 is augmented in the livers of PXR-null mice. Mice were i.p. injected with LPS (100 μg/kg) and GalN (700 mg/kg) or saline (n=5/group/time point). Livers were removed at the time point as indicated. Liver proteins were immunoblotted with indicated antibody and representative samples are shown in the figure.