Figure 6
LPS/GalN-induced hepatocyte apoptosis is augmented in PXR-null mice. Mice were i.p. injected with LPS (100 μg/kg) and GalN (700 mg/kg) or saline (n=5/group/time point). (a) Representative TUNEL staining of liver sections of wild-type and PXR-null mice i.p. injected with LPS/GalN or saline for 5 h. (b) Quantification of TUNEL-positive hepatocytes of liver sections of wild-type or PXR-null mice 5 h after LPS/GalN injection. *P<0.05, compared with wild-type mice of 0 h; #P<0.05, compared within same time point. (c) Immunoblot analysis of cleaved caspase-3. Representative samples are shown in the figure.
