Figure 3
From: Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers

Localization of HMGB1 in CCD-18Co (normal), HCT116 (cancerous) cell lines, normal colonic mucosa, and colon cancer tissues. Both nuclear and cytoplasmic localizations (arrow) were evident in the HCT116 cell line. In normal mucosa, only mucosa localization was evident in colonic epithelial cells. In cancer cells, both nuclear and cytoplasmic localization were evident.