Figure 1

Histopathology analysis of liver sections of control and DENV-2-infected mice. (a) Liver of non-infected mice, showing normal aspect (H&E, bar=90 μm). (b–d) Liver section of a mouse killed 2 days p.i. (b, H&E, bar=90 μm; c and d, Lennert's Giemsa, bar=200 μm and bar=100 μm, respectively). (e–g) Liver section collected 7 days p.i. (e, H&E, bar=90 μm; f, Lennert's Giemsa, bar=70 μm; g, P.A.S., bar=100 μm). (h and i) Liver section obtained 14 days p.i. (H&E, bar=90 μm and bar=70 μm, respectively). (j–l) Liver section observed 49 days p.i. (j, H&E, bar=90 μm; k and l, Masson's trichrome, bar=40 μm). CV, central vein; ST, steatosis; He, hemorrhage; E, intercellular edema; N, necrosis; Ne, neutrophil; ^*, hepatocyte swelling; Ey, erythrophagocytosis; stars, binucleated hepatocytes; Ly, lymphocyte; white arrows, eosinophilic granulation in hepatocytes.