Figure 6

Serum levels of (a) alanine aminotransferase (ALT) and (b) aspartate aminotransferase (AST) in mice experimentally infected with DENV-2, at the 2nd, 7th and 14th day p.i., as illustrated by different symbols. Asterisks indicate differences that are statistically significant (^*P<0.05). Correlation tests between ALT (c) or AST (d) levels at the 14th day p.i. and hepatic damages were performed by linear regression. For hepatic damage quantifications, the sum of values obtained for steatosis, hepatocyte swelling, necrosis, hemorrhage and edema for each animal at the 14th day p.i. was calculated and then plotted against serum enzyme levels.