Figure 1 | Laboratory Investigation

Figure 1

From: Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation

Figure 1

Sphinganine-1-phosphate administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion (sphinganine-1-P IR (i.v.+s.c.), N=6) or 0.1 mg/kg i.v. immediately before reperfusion (sphinganine-1-P IR (i.v.), N=6) protects against hepatic (a, ALT) and renal (b, creatinine) injury in C57BL/6 mice subjected to 60 min liver ischemia and 24 h reperfusion. Sphinganine-1-phoshate when only given 2 h after reperfusion s.c. (sphinganine-1-P IR (s.c.), N=6) did not produce liver or kidney protection. Data are presented as mean±s.e.m. *P<0.05 vs vehicle-treated IR (vehicle IR) group.

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