Figure 9 | Laboratory Investigation

Figure 9

From: Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation

Figure 9

Proposed cellular mechanisms of sphinganine-1-phosphate-mediated renal and hepatic protection after liver IR. On the basis of the data generated from our studies, we propose that sphinganine-1-phosphate activates the S1P1 receptor subtype in endothelial cells that couples to pertussis toxin-sensitive G-proteins, resulting in the phosphorylation of ERK MAPK, Akt, as well as HSP27. We also propose induction of HSP27 mRNA as well as protein after sphinganine-1-phosphate treatment.

Back to article page