Figure 7
From: Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice
Expression of hepatic fibrogenic genes in wt and Gclm (ko) null mice. TIMP-1 (a), PAI-1 (b), TGF-β (c), and Col1A1 (d) mRNAs from the livers of wt or Gclm null (ko) mice fed the MCS or MCD diet for 21 days. Relative expression was determined by the ΔΔCt method in which hepatic expression in wt, chow-fed, age-matched, male mice is 1.0. For panel a, ##P<0.01 compared with wt MCS; ΦP<0.05 compared with ko MCS. For panel b, *P<0.05 compared with wt MCD. For panel d, #P<0.05 compared with wt MCS.
