Table 3 Partial list of genes included in the enriched KEGG pathways, which are upregulated in the livers of Gclm null mice compared with wt mice
From: Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice
KEGG pathway | Genes |
|---|---|
Metabolism of xenobiotics by p450 | Cyp 2a5,Cyp 2b9, Cyp 2b13, Cyp 2c38, Cyp 3a16, Cyp 3a41 |
Glutathione metabolism | Glutathione-S-transferases (Gsta2, Gstm1, Gstm2, Gstm3, Gstm4) Sulphotranferases (Sult2A2, Sult 3A1) Glutathione reductase (Gsr1) Glutamate-cysteine ligase, catalytic subunit |
Arachidonic acid metabolism | Carbonyl reductases 1 and 3 Cyp 2c38, 2b9, 2b13 |
PPAR-signaling pathway | PPARγ Lipoprotein lipase CD36 antigen |
Pyrimidine pathway | Thioredoxin reductase 1 Cytidine deaminase 5′ nucleotidase Nucleoside triphosphate diphosphohydrolase 5 |
