Figure 8
From: Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse
Immunogold electron microscopy showing ultracytochemical localization of α-dystroglycan (DG) and β-DG in mdx (a–c) and control (b–d) vessels. (a, c) mdx vessels showing α-DG (a, arrowhead) and β-DG (c, arrowhead) gold particles scattered in the cytoplasms of swollen glial endfeet (a, c, asterisk). Note isolated gold particles of both α-DG (a, arrow) and β-DG (c, arrow) attached on the glial membranes facing the thick basement membrane (b), enveloping endothelial cells (e). (b, d) Control vessels showing numerous α-DG (b, arrow) and β-DG (d, arrow) gold particles decorating the glial endfeet (b, asterisk) facing the thin basement membrane (d, arrowhead) enveloping the vessels. e, endothelial cell. Scale bar: a–c, 0.21 μm; d, 0.16 μm.
