Figure 1

TF expression in human non-AMD and AMD retina. A representative section stained with the avidin–biotin complex method is illustrated (a) in human non-AMD retina and (b) in human AMD retina (advanced wet AMD). In all samples evaluated to date, IHC analysis shows more intense immunoreactivity against TF (brown-blackish staining indicated by arrows) in AMD compared with non-AMD retina. (c) RT-PCR was performed on one AMD retina and one non-AMD retina to quantify relative TF mRNA expression. Microdissected retinal lesions in AMD retina demonstrated a 32-fold increase in TF transcript level when compared with normal maculae from non-AMD retina.