Table 2 Lung myeloperoxidase concentrations and bronchoalveolar lavage fluid leukocyte numbers during sublethal Streptococcus pneumonia e infection

From: The role of CD44 in the acute and resolution phase of the host response during pneumococcal pneumonia

 

0 Day

2 Days

4 Days

10 Days

 

WT

CD44 KO

WT

CD44 KO

WT

CD44 KO

WT

CD44 KO

Lung (ng/ml)

 MPO

ND

ND

1734±297

1976±413

737±70

772±104

790±72

1059±97*

BALF leukocytes × 10 4 /ml

 Total

14.88±5.38

10.66±0.82

9.02±0.85

12.9±0.64**

21.0±2.25

19.1±1.51

12.7±1.15

11.0±0.67

 Neutrophils

0.25±0.14

0.19±0.13

0.59±0.38

3.16±0.40**

0.38±0.25

0.62±0.08*

0.14±0.04

0.64±0.25

 Lymphocytes

0.28±0.06

0.45±0.07

0.17±0.04

0.33±0.14

0.06±0.04

0.62±0.39*

0.28±0.06

0.38±0.04

 Macrophages

7.65±1.47

9.49±0.79

8.24±0.83

9.40±0.38

20.5±2.20

17.9±1.35

11.4±1.15

10.0±0.70

  1. Abbreviations: BALF, bronchoalveolar lavage fluid; KO, knockout; MPO, myeloperoxidase; ND, not determined; WT, wild type.
  2. MPO levels in lung and total leukocyte counts, neutrophil, lymphocyte and macrophage numbers in BALF at 2, 4 and 10 days after infection with 102 colony-forming units S. pneumoniae in WT and CD44 KO mice. Data are expressed as means±s.e.m.; n=7 to 12 mice/group per time point.
  3. *P<0.05, **P<0.01 versus WT at the same time point.
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