Figure 1

Morphological appearance of the stomach of adult transgenic (Tg) mouse and wild-type (Wt) littermate, and expression of the transgene (rat regI gene) at infant and adult stages without ulcer induction. (a) HE staining and (b) PCNA staining of the fundic mucosas of 10-week-old adult Tg mouse and Wt littermate. (c) Total RNA was extracted from stomachs of infant (3 weeks old) and adult (9 weeks old) Tg mice and analyzed by quantitative RT-PCR for expression of rat regI gene. Mean values±s.e.m. at each time point, normalized to the internal references (GAPDH). N=10 for infant mice, 7 for adult mice.